Who Will Recover Spontaneously From Hepatitis C Virus Infection?

August 30, 2007

Twenty to fifty percent of HCV infected patients recovers spontaneously. The hepatitis C patients and their relatives like to know if his/her infection would fall into the category for self recovery.

A research article to be published on August 21 in the World Journal of Gastroenterology addresses this question.

The research team led by Dr. Mihm from Georg-August-Universität spent more than 8 years working with a cohort of 67 patients who spontaneously recovered from HCV infection. In addition to these, the researchers included a similar number of patients with chronic HCV infection. Large sample size allowed these investigators to obtain results with great statistical significance, and to draw very reliable conclusions.

One conclusion reported by the investigators is, patients who self recovered usually have lower levels of HCV antibody. Thus patients with lower HCV antibody titer may have a brighter clinical outcome. However, for a practical standard to be established to define a low HCV antibody titer, more effort is needed by investigators in the future.

Discount Pharmacy - Buy Pharmacy at discount prices including free shipping.Discount Pharmacy provides confortable and easy way to order discount pharmacy online.Another interesting conclusion reached by these investigators is, co-infection by hepatitis B virus (HBV) is associated with a higher possibility of self recovery. The investigators suggested that the infection of HBV interferes with the HCV replication, which would finally lead to virus eradiacation.. HCV patients co-infected by hepatitis A virus also have a better chance of self recovery, possibly by a similar mechanism.

Active iv drug users are less likely to self recover, for a couple of reasons: 1, they have a higher incidence of re-infection; 2, drugs have been shown to inhibit the expression of antiviral cytokines such as IFN-a and IFN-g; 3, HCV replication has been shown to be enhanced both by morphine use and morphine withdrawal.

Several different genotypes of HCV were discovered. The HCV genotype studied by Dr. Milm¡¯s group is type 1b, which is the prevalent genotype in Germany, and in China.

Posted by toshko under Cold Sore News | Comments (0)

Moscow flexes its military muscle again, but few in west say it is fit for a fight

August 26, 2007

From the ground it looked an impossible manoeuvre. The Russian Sukhoi-35 shot vertically into the sky before flipping forward in midair. It then raced downwards with an ear-ripping roar. The crowds were impressed. Even the seasoned US pilots standing on the tarmac next to their grey-painted B-52 bomber looked on admiringly. Nearby an array of lethal Russian missiles had been laid out. Next to them Russian pilots chatted under the shade of a formidably armed MiG.




The Maks-2007 international airshow near Moscow was the biggest in Russia’s post-Soviet history - and an apparent symbol of Russia’s resurgent military might. Last week, President Vladimir Putin announced that Russia’s ageing fleet of strategic bombers had resumed “combat missions”. On Tuesday, the MoD said the RAF had sent out two Typhoon fighters after spotting a Tupolev-95 bomber heading towards British airspace.The encounter seemed to symbolise Russia’s renewed military threat and follows a tumultuous eight months in which a hawkish Mr Putin has denounced US power, torn up a conventional arms agreement with Nato, grabbed a symbolic chunk of the Arctic, and accused Britain of “stupidity” in its handling of the Alexander Litvinenko murder.

And yet defence experts were yesterday dismissive of Russian strength, branding its air force a “Potemkin village”. Since the collapse of the Soviet Union, Russia has been forced to slash defence spending, leaving an ill-equipped conscript army to fight in Chechnya. The army’s tanks are old; Russia’s ships and submarines have seen better days; the navy’s much-vaunted sea-launched Bulava missile still doesn’t seem to work, despite a decade of development.

Internet Pharmacy - Buy Pharmacy at reasanoble prices.Internet Pharmacy provides confortable and easy way to order pharmacy via internet.”In terms of military threat they are a joke,” Robert Hewson, the editor of Jane’s Air-Launched Weapons, said, assessing the array of Sukhoi and MiG fighters on display at the airshow, held at the former Soviet Zhukovsky air base. “Everything is a relic from the Soviet era. The level of technology you see in the UK, Sweden and the US is much higher.

“The Russians are very good at radar. They understand missiles and aerodynamic design. They are terrific engineers. But since the end of the cold war their military has got worse.”

The Russian tabloid Trud-7 came to the same conclusion on Thursday, describing the state of Russia’s armed forces as “lamentable”. Pronouncements that Russia had got back its old Soviet military glory were mere “armour rattling” it said.

The state of Russia’s air force is indicative. It has gone an entire decade without a single new plane. Its military aviation industry fared better than its civilian manufacturers, mainly due to large orders from China and India. Until recently the air force could not afford its own products. Its bombers were almost all built decades ago, although it has 60 to 80 Tu-90 “Bear bombers” built in the 90s.

Few experts believe the Bears could ever penetrate British defences. “[The Bear bomber] can carry a load of cruise missiles. But it sticks out like a sore thumb on the radar. It’s slow and cumbersome,” Douglas Barrie, of Aviation Week, said. “What has been portrayed as a return to strategic operations is really sabre-rattling of the most laughable cold war kind. Before Russia returns to Soviet military levels you are looking at a decade-plus of sustained, high-level military investment.”

It seems clear Mr Putin is determined to restore Russia’s status as a global power. Earlier this year Mr Ivanov - Russia’s first deputy prime minister, the man most likely to succeed Mr Putin - announced a £97bn revamp of the armed forces. From now until 2015, Moscow plans to modernise and exceed the Red Army in “combat readiness”, he said. Russia’s current defence budget is £16bn, almost four times the 2001 figure, all paid for by soaring oil and gas revenues.

Russia held wargames last week in the Urals involving troops from Russia and China and four central Asian states. Moscow has infuriated Georgia after a Russian missile landed on the outskirts of its capital, Tbilisi. Much of the military posturing is for internal consumption, ahead of parliamentary elections in December and a presidential poll in spring. Pictures showing a shirtless Mr Putin on a fishing trip have been a source of national pride.

The US appears relaxed about this newfound Russian machismo. After all, Washington’s defence budget is at least 20 times bigger than Moscow’s. And US generals are unperturbed by the Russian Bears close to its airspace. Brigadier-General Richard Sherlock, director of international security operations, was asked at a Pentagon briefing on Thursday about Russian flights close to Guam and Alaska. US planes had been scrambled, but he played down the significance: “Militaries all over the world conduct a variety of operations. This is not something new.”

Sean McCormack, the US state department spokesman, said last week: “If Russia feels as though they want to take some of these old aircraft out of mothballs and get them flying again, that’s their decision.”

Anatol Lieven, a Russia specialist at the Washington-based New America Foundation, said it was clear Moscow was going to ramp up its response to President George Bush’s controversial missile defence project in eastern Europe.

“It indicates to the US that this move is not cost-free and shows the Russian population that the government is still acting toughly to defend Russian prestige abroad,” he said. “It is depressing but it is not a new cold war.”

Posted by toshko under Cold Sore News | Comments (0)

Can common cold lead to obesity?

August 23, 2007

In a new finding, it appears that adenovirus that causes cold and sore throat could also lead to obesity in certain cases.

A new study has linked a virus that causes cold and sore throat to obesity. The discovery of adenovirus’ role in obesity can offer a vital clue in developing anti-obese vaccines in the future.

Earlier studies have revealed that poultry and mice infected with the virus gain weight even when they don’t eat much and research has also shown that people, who are obese, carry the virus more than their lean counterparts.

Now, researchers at Louisiana State University have found that the virus could cause the growth of fat cells in the body.

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The study revealed that stem cells or master cells that can mutate into other cells and tissue were infected with adenovirus as they altered into fat cells. “We’re not saying that a virus is the only cause of obesity, but this study provides stronger evidence that some obesity cases may involve viral infections,” a British daily quoted Dr Magdalena Pasarica, as saying.

“Not all infected people will develop obesity. We would ultimately like to identify the underlying factors that predispose some obese people to develop this virus and actually find a way to treat it,” Dr Pasarica added. However, experts also insisted that diet and exercise are equally important in avoiding obesity.

“A vaccine won’t stop people from eating the food put in front of them at fancy restaurants - it isn’t going to change people’s lifestyle,” said Dr David Haslam, of the National Obesity Forum. “Even if a tiny part of obesity is caused by a virus, the food you put in your mouth and the activity you don’t do is the key,” he added.

Posted by toshko under Cold Sore News | Comments (0)

Mouthing defiance

August 19, 2007

Yesterday I got a cold sore for my birthday. Oh, that wasn’t all I got, far from it, ho ho, oh no, and other fruity, rounded vowel sounds which it’s sadly far easier at the moment to type than to actually shape my cracked lips around - lots of friends, and cards, and a lovely lamp from the one who is swiftly becoming The One, and also, a new one this, emails of congratulation from the bank, from the place I bought my stupid fat telly and from a global coffee chain into one of whose leaflets I had once ill-advisedly consigned personal information including my birth date through an odd mix of boredom, the chance to win free cinnamon lattes for all of November or some such and, actually, genuine delight at having been allowed to simply order a coffee, and get it, without being turned into a bug-eyed Nebraskan psycho by being asked whether I wanted something else I had somehow unaccountably been unable to think of ordering for myself. (’Would you like a vanilla biscotti?’ ‘No.’ ‘What about a chocla-wafa double-layered…’ ‘No.’ ‘A waffle?’ ‘Please stop it now. Look at this thing I’m holding. It is a very big gun.’ ‘Yes sir, but we do have an offer on…’ ‘Less talk. More dying.’)

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I used to think it was fairly cynical and perhaps a little sad to be sent those Christmas cards you got from Indian restaurants where, in June, you’d left your business card in a glass bowl beside the lunchtime till and the mints: cynical on their part, perhaps a little sad on mine, especially to have pushed my parent’s card off the top of the telly to make way for it. But, compared with the savage screw-you caustic computerised greed dressed as affable acquaintanceship of this new net stuff - and, by the way, if there’s any piece of information more convincing of the hoo-buttock bawheeney surrounding it all than the news that Jimmy Carr apparently has 6,712 digital ‘friends’, then I’d dearly like to hear it - compared with all this, I will fall upon the coming December’s missive from the (rather fine) Gulshan Tandoori as on a smuggled note from some long-lost adored brother.But I remember mostly, at the moment, getting the cold sore, because it is on my mind - not literally, that would be a truly new medical phenomenon, albeit a weirdly cohesive explanation for the continuing behaviour of the head of security for BAA. Cold sores are horrid things. And they divide us. Like jazz, but significantly less pleasing if equally throbby, a cold sore is something you either get or don’t.

Those of you out there who get them know. For the rest of you: this is what happens. At the age of 14, or similar, some poor future innocent victim will have been given a well-intentioned smidgeon of a kiss by an aged aunt. The herpes simplex virus passes into your system, forever and will do no damage whatsoever other than, two or three times a year, deciding out of sheer viral merriment to plip back down your nervous system, and for the next 11 days it will ruin your entire life.

First, the tingle. You’re in the middle of chatting, and you take a sip of something or lick chocolate off your lips and - aww, NO. It’s not that it’s sore. But it will, undoubtedly, make you less than fabulously attractive. And it’s so undeserved. Those who don’t get them think that you, you with the scabby raw-sore bleeding blister-lip, have quite obviously just spent a month in some cheap Shanghai whorehouse, snogging the floor and licking rats’ skanky bottoms. This is so far from fair it angers me. The best, best people get them. It is a little-known fact that Saint Gudrun the Fabulously Chaste eventually died in 1407 from a cold sore so large it ended up blocking the light from one whole early window in Rheims Cathedral.

Not her fault. Not mine either. I will do what I can: buy Zovirax. I’m not sure if it works other than by being so expensive that it feels like putting gold leaf on your lips, and thereby stops you for financial if for no other reasons from continually howking and jabbing away at the tingle and then the scab, and goodness I do hope you’re well beyond your breakfast. This is what we do: all we can do. As for the rest of you, the blessedly unaffected, trust us. It is unsightly and a little unfortunate; it is not the tattooed devil-mark of Sir Crab McFilth. You can still kiss us. If you still want to kiss the kind of person stupid enough to realise only in the last sentence, rather gulp-suddenly, that, in the grand schemes of love, this is perhaps not quite the wisest column that has ever been committed to print

Posted by toshko under Cold Sore News | Comments (0)

Cold Sores

August 18, 2007

The type 1 herpes simplex virus causes cold sores around the mouth. This virus is very contagious and it is believed that the vast majority of the population carry it. Most people first become infected with the virus as children when they are in contact with adults who are carriers. It does, however, lie dormant for long periods of time and only becomes active when it is triggered by certain stimuli.

What are the main symptoms of a cold sore?

Those of you who suffer from cold sores regularly may be aware of a tingling sensation that occurs just before your cold sore develops. This is then followed by the formation of painful red blisters around the mouth that may weep but that will eventually crust over, usually within 24 hours. Most outbreaks will resolve within 7 days but early treatment with over-the-counter medication may speed your recovery.

What triggers a cold sore?

A number of triggers can cause the dormant herpes simplex virus to become active and cause cold sores. These triggers may include:

Stress

Emotional upset

Fatigue

Sunlight

Weakened immune system (when you are feeling run down)

If you are aware of the triggers that cause your cold sores do what you can to avoid these.

What treatments are available over-the-counter for cold sores?

Aciclovir

Discount Pharmacy - Buy Pharmacy at discount prices including free shipping.Discount Pharmacy provides confortable and easy way to order discount pharmacy online.Aciclovir is an antiviral treatment found in a topical cream over-the-counter. If applied at the tingling stage of your cold sore it may speed up the healing time of the cold sore. Aciclovir needs to be applied five times daily for five days to have an optimal effect.

Penciclovir

Penciclovir is another antiviral cream that has recently become available to sell as a pharmacy medicine. It should be applied every 2 hours (around eight times a day) for four days to have optimal effect.

As mentioned, these antiviral preparations may speed up the healing time of the cold sore however they will not stop you spreading your cold sore to another person.

When using the above creams it is important to wash your hands before and after using them to prevent the spread of the infection

Cold sore patches

Cold sore patches are an alternative to treating your cold sore with a cream. They can be effective at preventing cross-contamination as they reduce your ability to touch your cold sore and, therefore, reduce the spread of infection to you and to others.

Tops tips on avoiding and treating cold sores

* Don’t pick cold cores because this may spread the virus to other parts of your body

* Avoid the triggers that may set of a cold sore

* As soon as you notice the first tingle of a cold sore treat it with one of the antiviral preparations mentioned

* Wash your hands after touching your cold sore and don’t put your fingers near your eyes.

* Avoid direct contact with someone who has an active cold sore

* Use only your own face cloth and towel

When buying over-the-counter medicine it is important that you make your pharmacist aware if you have any underlying medical conditions, if you are taking any other medication or complementary therapy, or if your symptoms persist.

Let your pharmacist know if you are pregnant or breastfeeding and always read the product information before taking the medication.

It is also important to keep all medicines out of sight and out of reach of children.

Posted by toshko under Cold Sore News | Comments (0)

Cold Sores

August 10, 2007

The type 1 herpes simplex virus causes cold sores around the mouth. This virus is very contagious and it is believed that the vast majority of the population carry it. Most people first become infected with the virus as children when they are in contact with adults who are carriers. It does, however, lie dormant for long periods of time and only becomes active when it is triggered by certain stimuli.

What are the main symptoms of a cold sore?

Those of you who suffer from cold sores regularly may be aware of a tingling sensation that occurs just before your cold sore develops. This is then followed by the formation of painful red blisters around the mouth that may weep but that will eventually crust over, usually within 24 hours. Most outbreaks will resolve within 7 days but early treatment with over-the-counter medication may speed your recovery.

What triggers a cold sore?

A number of triggers can cause the dormant herpes simplex virus to become active and cause cold sores. These triggers may include:

Stress

Emotional upset

Fatigue

Sunlight

Weakened immune system (when you are feeling run down)

If you are aware of the triggers that cause your cold sores do what you can to avoid these.

What treatments are available over-the-counter for cold sores?

Aciclovir

Aciclovir is an antiviral treatment found in a topical cream over-the-counter. If applied at the tingling stage of your cold sore it may speed up the healing time of the cold sore. Aciclovir needs to be applied five times daily for five days to have an optimal effect.

Penciclovir

Internet Pharmacy - Buy Pharmacy at reasanoble prices.Internet Pharmacy provides confortable and easy way to order pharmacy via internet.Penciclovir is another antiviral cream that has recently become available to sell as a pharmacy medicine. It should be applied every 2 hours (around eight times a day) for four days to have optimal effect.

As mentioned, these antiviral preparations may speed up the healing time of the cold sore however they will not stop you spreading your cold sore to another person.

When using the above creams it is important to wash your hands before and after using them to prevent the spread of the infection

Cold sore patches

Cold sore patches are an alternative to treating your cold sore with a cream. They can be effective at preventing cross-contamination as they reduce your ability to touch your cold sore and, therefore, reduce the spread of infection to you and to others.

Tops tips on avoiding and treating cold sores

* Don’t pick cold cores because this may spread the virus to other parts of your body

* Avoid the triggers that may set of a cold sore

* As soon as you notice the first tingle of a cold sore treat it with one of the antiviral preparations mentioned

* Wash your hands after touching your cold sore and don’t put your fingers near your eyes.

* Avoid direct contact with someone who has an active cold sore

* Use only your own face cloth and towel

When buying over-the-counter medicine it is important that you make your pharmacist aware if you have any underlying medical conditions, if you are taking any other medication or complementary therapy, or if your symptoms persist.

Let your pharmacist know if you are pregnant or breastfeeding and always read the product information before taking the medication.

It is also important to keep all medicines out of sight and out of reach of children.

Posted by toshko under Cold Sore News | Comments (0)

Cold sores

August 7, 2007

Cold sores are caused by a member of the herpes virus family, called herpes simplex. They occur on the lip, or just above or below it, and are caught through close contact with someone who has a cold sore.

Illnesses, such as colds and flu Menstrual periods Emotional upset, Fatigue, Bright sunlight, Cold winds.

Infection usually occurs in childhood when someone’s kissed by a family member who has a cold sore. The virus passes through the skin, travels up a nerve and hides in the nerve root until it’s activated.

When the virus is activated, it travels back to the skin, causing a tingling sensation. When the sore appears, it’s itchy, painful and embarrassing because it’s so noticeable.

After the first attack, some people never have another one; others get them occasionally, while some get them quite often.